Are improper kinetic models hampering drug development?

Are improper kinetic models hampering drug development?

Reproducibility of biological data is a significant problem in research today. One potential contributor to this, which has received little attention, is the over complication of enzyme kinetic inhibition models. The over complication of inhibitory models stems from the common use of the inhibitory term (1 + [I]/Ki ), an equilibrium binding term that does not distinguish between inhibitor bindi...

Improper Priors Are Not Improper

It is well known that improper priors in Bayesian statistics may lead to proper posterior distributions and useful inference procedures. This motivates us to give an elementary introduction to a theoretical frame for statistics that includes improper priors. Axioms that allow improper priors are given by a relaxed version of Kolmogorov’s formulation of probability theory. The theory of conditio...

HCV Kinetic Models and Their Implications in Drug Development

Chronic infection with hepatitis C virus (HCV) affects about 170 million people worldwide and is a major cause of liver complications. Mathematical modeling of viral kinetics under treatment has provided insight into the viral life cycle, treatment effectiveness, and drugs' mechanisms of action. Here we review the implications of viral kinetic models at the different stages of development of an...

Are intellectual property rights hampering cancer research?

Animal Models in Drug Development